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Home > Learn about kidney disease > Diabetic Nephropathy

Diabetic Nephropathy

Diabetic Nephropathy also known as Kimmelstiel–Wilson syndrome, It is a progressive kidney disease and characterized by  nephrotic syndrome and diffuse glomerulosclerosis.

Basics

DN,caused by diabetes,is one of the most common and harmful complications of diabetes.It has become the second cause of ESRD.In addition,the complex metabolic disorders makes the treatments on DN be more difficult than other renal disease.
What is DN?
DN is mainly caused by the long-term diabetes more than 10-15 years,that will lead to the damage on glomerulus.What's worse,it may bring about ESRD after 5-20 years.
What causes DN? 
The causes and pathogenesis are not clear at present.Recent years' research shows that DN is mainly caused by 3 factors:high sugar,high blood pressure and the certain genetic factor.
--high sugar may causes the damage on the whole body blood capillary by changing the renal hemodynamics or the disorganize the metabolism.
--high blood pressure
High blood pressure may bring some severe complications that can not be controlled effectively,which makes the prognosis for patients with DN be worse.
--genetic factor
The morbidity in male is higher than female.In the same environment,some family are easy to suffer from the DN,etc.
Diagnosis
The microalbumin is the sign of DN.Besides,the patients diagnosed with diabetes with the damaged kidneys or the high sugar may also be easy to suffer from the DN.
Prognosis
Owing to the chronicity of DN,when urine protein appears,the course of history is often more than 10 years.Thus the majority of prognosis is not well.According to the study, in 6 years,about 25% patients'condition worsen into renal failure stage;while 50% and 75% patients suffer from ESRD in 10 years and 15 years separately.The average time is ten years from the appearance of proteinuria to patients died of uremia,that is ESRD.
But as the experts say,if take the proper treatment,patients can live longer than expected.What's more,the healthy diet and the optimistic mindset also play an important role in controlling the disease and prolonging the life-pan of patients.

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Symptoms

DN,caused by diabetes,is a kind of secondary disease,owing to the various congenital or acquired reasons.DN is one of the diabetic microangiopathy complications,so the DN often accompanies with other organs or systematic microangiopathy,such as diabetic retinopathy and peripheral neuropathy.There are several symptoms should be paid attention to.
1.proteinuria or hematuria
The earliest leakage of protein appears in patients with DN among all renal diseases.In the early stage,there is may a little and intermittent proteinuria.As the disease goes on,continuous proteinuria occurs,which means that the kidneys are damaged.According to study,5-10 years'DN may lead to the renal failure.
2.high blood pressure  
The damaged kidneys can not work normally,which causes the disorder of endocrine.The disordered endocrine influences the creation of renin and causes the blood pressure out of control.The high blood pressure may worsen the patients condition even leading to other serious complications.
3.anemia
The damaged renal function causes the endocrine dysfunction,which influences the production of EPO.The lack of EPO may cause the insufficient blood supply to some degree,which may cause the anemia.
4.edema
The damaged kidneys can not keep the balance of water,electrolyte and acid-base.Thus the over much water can not be eliminated from the body,which may causes the local edema.As the illness deteriorates,the retention of water is worse and worse.Besides,the unbalanced electrolyte may lead to sodium increases,which will also worsen the edema.
5.renal insufficiency
The damage caused by long-term diabetes will involve kidneys even resulting in renal insufficiency.Generally speaking,patients with diabetes will suffer from DN after 5-10 years.With the disease going on,renal glomerular function will be damage and reduce continuous.When this condition continues in 5-20 years,patients condition may deteriorate into ESRD.
6.complications
About 95% or more patients with DN accompanies with the diabetic complications,such as retinopathy,CVD or nervous system disease,etc.

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Healthy Diet

DN,the common complication of diabetes,is one of the most important death causes of diabetes.Owing to the unobvious symptoms in early stage,the DN often be ignored.While when edema,serious proteinuria,high blood pressure,hypoproteinemia and NS(nephrotic syndrome)or uremia appear,the disease may often belongs to middle or end stage and the prognosis is not well.
DN puts emphasis on the diagnosis and treatments in the early stage.Besides the necessary medical treatments,dietotherapy plays an important role in therapy.It is useful to reduce the renal burden and beneficial to control the disease and relieve the damage caused by the long-term medicine.The main rules are as following:
1.Control the intake of vegetable protein.Owing to the leakage of massive proteinuria,patients should increase the intake of protein.But the vegetable protein is not suitable to patients,because the vegetable protein is rich in purine base that will increase the renal burden.So the intake of soybean,soybean milk and so on should be limited and they can be replaced by fish,shrimp,trepang,etc.
2.Limit the fat.When patients suffer from the renal disease,the intake of fat should be limited.Because the fat may worsen the arteriosclerosis and aggravate the patients condition.
3.Limit the high purine food.a lot of purine may increase the renal burden.Celery,spinach,peanut,sardine and so on are limited to eat.
4.Eat less salt and eggs.If the high blood pressure and edema occur,the intake of salt should take strictly.What's more,the eggs will produce much uric acid that will cause the accumulation during the metabolism.
Although we have many information about the healthy diet,the patients condition is different.According to the stage and features of pathological or physiological changes,it should take the individualized diet plan.
If you have other questions about your disease,you can talk to online doctor to get the free and professional guidance.

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Treatment

DN is a secondary disease caused by diabetes.So the therapy used to treat DN is taken to solve the diabetes to control the disease process.There are mainly 3 reasons that worsen the diabetes into DN:high sugar,high blood pressure and the genetic factor.The article will show you several methods to treat the disease.
1.Control the blood sugar and blood pressure.
High sugar causes the damage on whole body blood capillary and the high blood pressure may lead to the serious complications.So controlling the two factors is necessary to limit the development of DN.Western Medicine plays an important role in stop the protopathy,like ACEI or insulin .
2.replacement therapy
As the advanced methods to treat the DN,dialysis and the renal transplantis the significant way to control the disease process.Dialysis is used to replace the part of renal function to maintain the patients life.And the renal transplantis a more thorough way to resolve the renal disease.However,regardless of dialysis or renal transplantboth are problematic even harmful to patients body.There are too many effects that may overdraft the patients remaining health.
3.TCM
TCM(Traditional Chinese Medicine) is a kind of traditional medical science,which uses natural herbs or acupuncture and moxibustion,etc to treat the disease.TCM offers several methods to remedy the DN fundamentally.Micro-Chinese Medicine Osmotherapy,Immunotherapy,Blood Pollution Therapy and so on are taken to control the disease effectively and relieve the pain of patients.In addition,these therapies can also improve the life quality and prolong the life span of patients as far as possible.Compare with Western Medicine,TCM has less effects during the therapeutic process.
4.Dietotherapy
Besides the necessary pharmacotherapy,the healthy diet is beneficial to the patients condition.The proper exercise and the rest can also increase resistance to avoid infection.
The therapy is different,which depends on the specific condition.So if you have been diagnosed with DN,don't worry,you can talk to the online doctor or leave messages on below about your disease condition and get the free,professional guidance from experts.

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Healthy Living

DN is one of the common chronic diseases in life,which will cause some serious complications that may endanger the patients lives.So if you suffer from the diabetes,the healthy living should be taken to avoid the deterioration of diabetes.Besides the positive treatments,patients should change their life style to control the disease condition.Now we will introduce several healthy living style for patients.
1.Healthy Diet
The patients should pay attention to their daily diet at first.The balanced diet and the regular meal time are good for controlling the disease condition.Patients should eat more foods that are rich in unsaturated fattyacid,antioxidant ingredient,vitamin and cellulose.The foods contain abundant saturated fat and cholesterol are not suitable to patients,because these foods will increase the risk of CVD and atherosclerosis.
2.Lose weight
Overweight may delay the human reaction to insulin,increasing the difficulty to control the disease.Lose weight properly can enhance the sensitivity to insulin, improve the control to blood sugar and reduce the dependence on drug contains insulin.
3.Reduce pressure
When you are nervous,paranephros will secrete more cortin,that is,stress hormone.The stress hormone will increase the excitability of sympathetic nerve and the requirement of insulin,improve the blood sugar and increase the burden of islet cells,thus the disease condition be worsen.
4.Enough sleep
Lack of sleep will increase blood sugar directly and improve the content of stress hormones,which are both the factors deteriorate the disease.
5.Quit smoking
Besides the damage of smoking on body,it will lead to the poor circulation in body,thus worsen the damage of diabetes.
6.Take proper exercise
According to the study,the patients with regular exercise has a low risk to suffer from the severe complications.But please confirm the proper project under your doctor advice.

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