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Home > Learn about kidney disease > Lupus Nephritis

Lupus Nephritis

Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease of the immune system.

Basic

LN,a secondary renal disease,is caused by SLE(Systemic Lupus Erythematosus) that is a type of autoimmune disease.
What's LN?
Just as its name implies,LN means that the SLE has already damaged the patients'kidneys gradually.The patients'kidneys is damaged worse and worse with the disease process.Finally,LN may deteriorated into ESRF.
What cause LN?
In fact,there is no certain conclusion about the causes of LN and SLE.According to recent researches,experts think that the main reason of LN,called Lupus Nephritis,is the deposition of immune complex on glomerulus capillary epithelial cells.Besides,heredity,habitus and the environment effect and worsen the disease process to some degree.
As the disease goes on,the lesions will damage the glomerulus and affect multisystem and multiple organs in body.The damaged barrier function can not work normally and effectively and it lead to renal damage is worse and worse.Thus the renal function causes lesion and be damaged badly.What's worse,part or complete function loss of kidneys,even ESRF.
Diagnosis
Diagnosis of LN mainly depends on the definite diagnosis of SLE.In addition,there are 2 points that need attention.
1In some cases,renal biopsy are necessary to make the definite diagnosis.
2.Glomerular disease is the significant symbol of SLE.
In addition to the above 2 points,according to detailed patients' cases,laboratory examination and pathological examination can also make right diagnosis.
Prognosis
Due to the chronicity of LN,we can't make sure how long the patients can live certainly. In generally,if you are diagnosed with LN,the survival rate of 5-10 years is 75%-85%.Moreover,with the disease process,leakage of massive proteinuria and hypertension may occur,which indicates that the disease is worsen.What's worse,some complications,like high blood pressure and high blood sugar,may increase the risk of exacerbation.about 20% patients with LN may evolve into uremia in 10 years,which is the main result of death.
Actually,different patients have different disease condition that lead to the various results of prognosis.An early and effectively treatment can make great difference to the life expectancy of LN patients.If you have problems about your disease,you can contact online doctor to get professional guidance freely.

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Symptoms

LN(lupus nephritis),caused by SLE,is a type of secondary renal disease.So in early stage,the illness is higher and some symptoms are just in body surface.With the disease going on,the lesions may damage the kidneys worse and worse.There are some main clinical symptoms of LN as follows.
1.Fever
About 90% of patients may have fever.One reason is active disease that may cause the fever.Besides,long-term use of hormone may reduce the immunity of patients' body,which makes the infection more likely to occur.
2.Mucocutaneous damage caused by protopathy
3.Incidence rate of various mucocutaneous damage is more than 80% of SLE.In addition,patients with SLE may also be sensitive to light and ultraviolet light will worsen the disease.Moreover,hematuresis may appear at the same time owing to the damaged glomerulus.
4.Arthritis
About 95% of patients may suffer from arthritis,which is almost caused by the activity of disease.
5.Massive proteinuria
As the disease progress,the leakage of protein is worse and worse.Lesions damage the kidneys gradually and the mild and moderate proteinuria occurs.What's worse,in later stage,with the glomerular lesion increasing,massive proteinuria may appear,which signifies that the renal damage is anabatic.
6.Hypoproteinemia
The leakage of lots of proteinuria lead to the shortage of protein and the less protein con not maintain patients condition normally.Which may cause hypoproteinemia that can influence the kidneys.
7.HLP ( hyperlipidaemia )
Due to the shortage of protein,liver will produce more protein with some lipid.What's more,the damaged kidneys reduce the elimination of lipid.Both of above lead to the increased high fat in body.
8.Edema
The damaged kidney can not discharge the overmuch water in body and the intake of sodium both cause and worsen the edema.
9.High blood pressure
In later stage of LN,patients may suffer from NS,that is nephrotic syndrome.High blood pressure may increase the risk of complications.
10.Increased nocturnal enuresis
As the disease progress,the renal damage may effect kidney tubules,which influences the re-absorption function.On the other hand,the damaged glomerulus results in the reduced GFR and the can not work normally and effectively.
All above are some symptoms of LN,and if you have other questions about your disease,you can contact online doctor to get the professional guidance freely.

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Diet

According to the survey,in addition to the high recurrence rate of LN,about 20% of patients may worsen into uremia,that is,ESRF,which is one of the main causes of death.To treat the LN,except the normal medication followed the doctor's advice,daily nursing and healthy diet are necessary in order to control the LN and avoid relapse.
1.Offer the high-quality protein
The patients suffering from SLE with the damaged kidneys often loss lot of protein,which may cause hypoproteinemia.So it is important to provide the high-quality protein.Such as milk,fish,lean meat,and so on.
2.Limit the intake of low-fat
Owing to the disease,it is not suitable to take violent activities for patients and the digestive function of patients is poor.What's more,too much fat may increase the renal burden and worsen the disease.So taking light and digestive food is good for patients with LN.
3.Take a low-sugar diet
Due to the long-term use of glucocorticoid,patients is easier to have Cushing's syndrome and steroid diabetes mellitus.Besides,high sugar may accelerate the deterioration of LN.Thus controlling the appetite properly is very useful.
4.Control the intake of salt and water
The damaged kidneys can not eliminate the overmuch water,metabolite and waste and it also may lead to retention of water and sodium,which may cause edema.So to limit the intake of salt and water is necessary to keep the whole system in balance and relieve the symptoms as far as possible.
5.Increase the intake of calcium
Taking the glucocorticoid may cause osteoporosis,so vegetables and fruits that are rich in vitamin should be eat more.
6.Unfavorable diet
Photographic food is not suitable yo be eaten,such as fig,celery,etc.Some mushrooms, food dyes and tobacco may can induce the SLE too.Thus bo not eat or eat less of them.Furthermore,to stop smoking and drinking is significant to control the disease condition.
Although we can enumerate many examples,the specific disease condition is different.So if you are doubtful of your condition or have other questions about your disease,you can contact live doctor to get the professional guidance freely.

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Treatment

As a secondary renal disease,the treatment for LN is based on the clinical manifestation and diagnosis,laboratory examination and pathological change,etc.
1.Pharmacotherapy
The principle of pharmacotherapy is to avoid aggravating the disease especially in acute active stage.Glucocorticoid,cytotoxic drug are both used to control the disease process.However,pharmacotherapy usually has some or light or heavy side-affects that may increase the patients condition.So taking measure must follow the doctor's advice based on patients condition.
2.Blood purification
Some therapies,such as plasmapheresis,immune adsorption,blood perfusion and so on,can be used to eliminate waste,toxin in blood.Blood purification can improve the blood flow and control the disease timely and effectively.
3.Dialysis and Renal Transplant
As the disease progress,LN may worsen into Renal Failure.In this case,dialysis and renal transplant are effective to control and relieve the disease condition.But as we all know,there are many serious complications that may influence even aggravate patients condition.
4.Micro-Chinese Medicine Osmotherapy
Micro-Chinese Medicine Osmotherapy is a type of characteristic TCM therapy that is made by natural herbs.It is more significant to control and delay the disease process.Compared with Western Medicine,it reduces many side-affects and relieve the pain to patients.Moreover,it does better in improving the living quality and prolonging the life-pan of patients effectively.
5.Immunotherapy
Immunotherapy is a good way to control the disease condition.It mainly includes 6 steps to slove the renal problems gradually:Scientific tests,Blocking immune reaction,Immune tolerance,Immune regulation,Immune protection,Immune clearance.These steps do much to relieve the symptoms and increase the living conditions.
6.Dietotherapy
Except the necessary pharmacotherapy,dietotherapy plays an important role in sopping the disease from process.
Control the intake of albumin and fat,avoid increasing the renal burden.In addition,limit the salt and the water intake,control the sodium,potassium and phosphorus intake to prevent the disease from progressing.What's more,eat less or no Photographic food,such as celery,fig,mushroom and so on and supplement the vitamin.
If you have other questions about your disease,you can contact online doctor to get professional guidance freely.

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Healthy Living

Every act and every move may cause the deterioration or relapse of the illness.So we should pay more attention to it.There are several points that need to notice.
1.Do not fear of disease.
Keep a happy mood and don't be nervous.Moreover,develop the confidence in fighting against the disease.The nervous spirit and stressed state may influence the immune system or worsen the disease though the neuroendocrine system.The happy and optimistic mood can increase the immunity and reduce the burden of infection effectively,which are useful to control the disease process and relive the symptoms.
2.Avoid insolation and ultraviolet light
LN is caused by the long-term SLE and the symptoms of SLE are sensitive to lights.So avoid going out at 10:00 am -- 4:00 pm to improve the patients condition and ease the symptoms.
3.Take a long-term treatment
LN has a strong genetic background.Up to now,drug therapy can relieve the disease condition better but it can not cure the disease completely.So long-term treatment is necessary.Some patients may be doubtful of the side-affects or listen to the deceptious doctors to give up medicine,which usually lead to the relapse of disease.So patients should follow the specialist's advice and take measure to control the disease condition timely and professionally.
4.Pay attention to toxic effects of drugs
Some medicine have severe side-affects to patients.So when patients take the medicines,they should take care about its toxicity.
5.Take proper exercise and rest
6.According to the patients condition,advise the patients take exercise and rest properly.Some female can also have children under the guidance of a doctor.But it is important to avoid hard work and fatigue,have a regular daily life and ensure the adequate sleep.
7.Have a healthy diet
Healthy diet is important to control the disease condition.Choose the high-protein,low-fat,low-sugar and low-salt diet.What's more,provide calcium and vitamin on the basis of physical condition.
There are too many specific points need attention,so if you have other questions about your disease,please talk yo live doctor to get what you what to know freely.

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