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IgA nephropathy is mainly caused by autoimmune disorders which means the IgA immune globulin goes wrong. What's worse, the damaged kidneys may result in renal failure.
IgA nephropathy is a kind of primary glomerular diseases caused by the autoimmune defects.
What's IgA nephropathy?
IgA nephropathy,called Berger's disease,is characterized by the deposition of immunoglobulin in GMA (glomerular mesangial area).
What causes IgA nephropathy?
IgA nephropathy is mainly caused by autoimmune disorders which means the IgA immune globulin goes wrong.The diseased IgA immune globulin will combine with autoantibody to form immune complex that may deposited in the GMA.In addition that the GMA has some affinity with these immune complex.The deposition of immune complex will secrete inflammatory factors,as the disease worsen,the damage is related to kidneys.What's worse,the damaged kidneys may result in renal failure.
Diagnosis-disease diagnosis
It is necessary to take the renal biopsy to diagnose the pathology.There must be immunofluorescence or immunohistochemical results to support this conclusion.
auxiliary examination
1.Immunologic test
About 50% patients have high level of serum IgA.37-75% patients era diagnosed with the specific CIC(circulating immune complex) that contains IgA.
2.Proteinuria
The examination of proteinuria is important to judge the disease condition and estimate the prognosis.The mild disease focal mesangial proliferation is the main symptoms when proteinuria < 1g/24h.Diffuse mesangial proliferation with crescent or glomerular sclerosis occurs in moderate or severe proteinuria.
3.Renal function
When serum creatinine is higher than 1.5mg/dl(132.6umol/L),the disease is progressing.Patients condition is worsen into stage 3 or worse with the GFR < 20ml/min.
4.Hematuresis
That RBC in urine has various shapes show that the disease roots in glomerular.
Prognosis
There are several factors that influences the prognosis of IgA.
1.Gerontal patient and the patients with older age will influence the prognosis and may cause the bad prognosis.
2.Patients who are with continuous hematuresis and proteinuria will have the poor prognosis.
3.Renal failure has appeared in patients,which signifies the poor prognosis.
4,High blood pressure will increase the risk of complications and worsen the disease.
IgA nephropathy is a type of primary glomerular disease,caused by the autoimmune defect.It is featured by the deposition of immunoglobulin in GMA (glomerular mesangial area).As the disease worsen,the damage in related into glomerulus,even kidneys.There are several symptoms to show you the manifestation in clinic to prevent the disease better.
1.Recurrent gross hematuria or microscopic hematuria
The unordered immune system causes the infection of urinary system,respiratory tract or gastrointestinal tract,which may lead to gross hematuria.
2.Different levels of proteinuria
Because of the impaired glomerulus,the leakage of protein occurs.Besides,with the disease increasing,the renal damage is worse and worse and the leakage of protein become more serious.The massive proteinuria signifies that the renal function is damaged so badly that the kidneys can not work effectively and regularly.
3.The imbalance of electrolyte
The damaged glomerulus can not filtrate the electrolyte effectively and the renal tubules may be affected,which causes the balance,As the disease deteriorate,this case will become severer and bring about some serious complications even life-threatening.For example,too much or too little potassium may cause the hyperkalemia or pins and needles.
4.Poor healthy
The continuous decline of renal function lead to the accumulation of a large number of toxin and waste,which way make the patients feel uncomfortable.Then some complications may occur,such as nausea,emesis,bad night's sleeps,pruritus, fatigue.
5.Edema
In clinic,edema is a common symptom in patients with IgA nephropathy owing to the damaged kidneys.With the edema,the hypourocrinia or frequent urination(especially in night) maybe arise too.
With different condition,patients may show different symptoms with varying degrees.So if you have other questions about your disease,you can contact online doctor to get the free,professional guidance for your condition.
IgA nephropathy is a kind of common glomerular disease in whole world.AS a chronic disease,IgA nephropathy often develops into chronic renal insufficiency.So paying attention to the healthy diet is important in slowing down the the disease process.
1.Taking less salt is useful to patients condition.Less salt can relieve the renal burden and control the disease process.In addition,a high in take of salt will aggravate the danger of edema and high blood pressure.What's more,keeping the balance of electrolyte and acid-base plays an important role in controlling the disease process.
2.Control the intake of water.The damaged kidneys can not discharge the excess water in body,which worsens the edema to patients.The intake of water should be limited according to the patients condition.
3.Limit the intake of protein and provide the high-quality protein for patients.The too much protein will increase the renal burden and worsen the disease.The proper high-quality protein can offer the enough energy to patients to keep their current situation and avoid aggravation.
4.The fresh vegetables and the appropriate fruits are good for patients condition.The various vitamin can not only adjust and strengthen the body's immunity,but also promote the renal recovery.
5.The tonic,high-fat foods may influences the renal repair and increase the renal burden.What's worse,it may also lead to other severe complications and increase the risk of death.
6.Besides,alcohol and tobacco should be limited to take.Drinking and smoking may increase the renal burden and exacerbate the damage on kidneys.
Although we have been able to enumerate many rule and cases to tell patients the good choice for their healthy.However,the patients condition are different owing to the patients physical qualifications.So in some cases,the rule is different.Do not follow other's therapy.If you have other questions about your disease,you an contact to online doctor to get free and professional guidance for yourself.
IgA nephropathy is a type autoimmune disease.All treatments are used to protect the renal functions and slow down the disease process.
Western medicine is used to cure specific disease according to the different symptoms and the stage,"treat the head when the head aches, treat the foot when the foot hurts."Based on what disease you have suffered,which medicine will be used to resolve the problems.Such as triple therapy(Tripterygium Glycosides,rheum emodin,ACEI/ARB )is used to cure the abnormal urine;prednisone is used to solve the vast proteinuria;ACEI/ARB,CCB,diuretic are used to control the high blood pressure,and so on.Besides,the replacement therapy are used to treat the severe IgA nephropathy,like dialysis and the renal transplant.They both can stop the disease processing and relieve the symptoms to prolong the life-pan of patients.
Besides Western medicine,Traditional Chinese Medicine offers several therapies to protect the kidneys and repair the renal functions.Micro-Chinese Medicine Osmotherapy is a kind of external Chinese medicine therapy,which avoid drug side-affects largely and make a great difference on remedy the IgA nephropathy.It can control the blood pressure,improve the microcirculation and increase the supply of oxygen and blood to kidneys.Besides,controlling the inflammatory reaction,reducing the invasion of Inflammation and stop ping the patients condition from continuing play an important role in prevent the inflammatory reaction.Thirdly,it can dissolve intravascular thrombus,improve the blood flow,increase the effective perfusion to kidney of blood and provide a better surroundings to the damaged kidney.What's wore,degrading the extracellular matrix and offering a lager space for nephrocyte to repair.
Except Micro-Chinese Medicine Osmotherapy,Blood Pollution Theory and Immunotherapy both are useful to treat the disease condition and relieve the symptoms.In addition,they can ease the pain and prolong the life-pan of patients s far as possible.
Which therapy is suitable to you depends on your disease condition.You can talk to live doctor to get professional and effective method freely.
To treat the IgA nephropathy effectively,it is necessary to take drug therapy.However,the healthy living is also significant to patients condition.
1.Focus on work and rest.
The overwork and the strenuous exercise may increase the hematuresis,damaging the kidneys.So it is important to take the proper exercise and rest,preventing staying up late,over fatigue or strenuous exercise.
2.Care the patients'spirits
Almost patients with renal disease have different psychentonia,depression and pessimism.It is beneficial to the recovery of the illness to keep a optimistic mood for patients.
3.Prevent the infection
The upper respiratory infection and amygdalitis often worsen the disease.So preventing the infection is necessary to patients.Take proper exercise to increase resistance,avoiding the infection.
4.Forbid the abuse of drug
Some antibiotic,analgesic-antipyretic have toxic effects to kidneys and they may cause the acute renal failure.So taking medicine is must under the doctors' guidance.
Control thehypertension,hyperglycaemia,hyperlipidemia and hyperuricemia actively to protect the renal function.
5.Take the test regularly,such as urine routine,renal function,etc.What's more,go to see a doctor and evaluate the disease process and the changes.
Arrange the diet and nutrition reasonablly,which is beneficial to reduce the proteinuria,protect and relieve the renal function and avoid the malnutrition.Take a light and healthy diet,guarantee the intake of nutrition and normal diet of protein.When the renal function is damaged and reduced,the low protein is necessary. The patients with high blood pressure should take a low salt intake to control their blood pressure.Besides,the seafoods,high-fat foods should be eaten less.At the meanwhile,avoid touch of the toxin and the pollen.
Healthy living plays an important role in control the patients condition.Although we can list such a listing to tell patients,but the specific condition is different.If you have other problems about your disease,you can contact online doctor to get professional guidance for free.
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