Basic Knowledge and Causes about IgAN

2014-04-03 15:44

IgA nephropathy is a relatively news recognized disease, first described by Berger and Hinglais in 1968. It is now generally known to be most common form of primary glomerulonephritis throughout the world. IgAN is a kidney disease that occurs when an antibody called immunoglobulin A (IgA) lodges in your kidneys. This results in local inflammation that, over time, may hamper your kidneys' ability to filter waste, excess water and electrolytes from your blood.

IgA nephropathy usually progresses slowly over many years. Patients will experience blood and protein in urine, high blood pressure and swollen feet. But different people present different symptoms. Some patients leak blood in their urine and will not develop, some eventually achieve complete remission, and others develop end-stage kidney failure.

IgA and IgA Production in IgAN

A number of abnormalities in circulating IgA and its production are reported in IgAN. However, patients are heterogeneous with respect to these abnormalities, supporting the notion that more than one pathogenic mechanism may result in the production of pathogenic circulating IgA. An increased plasma IgA level is not sufficient per se to produce mesangial IgA deposits; therefore, patients with IgAN must produce a pool of circulating IgA molecules with special characteristics that particularly promote mesangial deposition.

Causes

These conditions or factors may be related with IgA nephropathy:

· Genes:If someone is detected IgA nephropathy, their other family members may also has IgA.

· Liver diseases, including cirrhosis, a condition that scar tissue replaces normal tissue within the liver, and chronic hepatitis B and C infections.

· Celiac disease, a digestive condition triggered by eating gluten, a protein found in most grains.

· Dermatitis herpetiformis, an itchy, blistering skin disease that stems from gluten intolerance

· Infections, including HIV infection and some bacterial infections

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