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Home > Learn about kidney disease > Nephrotic Syndrome > Nephrotic Syndrome Symptoms >

Hypercoagulable State Is The Obvious Symptom Of Patients With Nephrotic Syndrome

2018-09-25 15:21

To most kidney patients they must take good care of their condition and diet,otherwise they may get more damage to their condition.and the patients with Nephrotic syndrome are prone to have hypercoagulable state,that is very dangerous to their lives,then we must know the reasons about the nephrotic syndrome and then we can accept the reasonable treatment in time.

There are many reasons why patients with nephrotic syndrome are prone to hypercoagulable state, including the increase of aggregation – promoting and coagulation – promoting factors in blood, while the mechanisms of anti – aggregation, anticoagulation and fibrinolysis are impaired. As well as venous blood stasis, hyperlipidemia, hypoproteinemia, blood concentration, increased blood viscosity, and the use of hormones and diuretics. The most direct evidence of hypercoagulability in nephrotic syndrome is an increase in plasma fibrinogen levels. The rate of plasma fibrinogen catabolism in patients with nephrotic syndrome is normal, and the increase of plasma fibrinogen level is due to the increase of its synthesis.

In addition, fibrin and fibrinogen degradation products also increased significantly. Plasma fibrinogen and metabolic disorder can disappear with the recovery of nephrotic syndrome. Coagulation factors Ⅴ, Ⅶ, Ⅷ and Ⅹ also increased, which may be related to the increase of liver synthesis. Increased platelet aggregation is also one of the reasons for hypercoagulability in nephrotic syndrome, which may be related to hypoproteinemia, hyperlipidemia and the decrease of sialoglycoprotein content in platelet membrane to prevent platelet aggregation. Fibrinolytic and anticoagulant system abnormalities include a decrease in plasminogen level ( although the level of plasminogen activator increases ), an increase in A2 – macroglobulin, and a decrease in antithrombin III ( lost from urine ). Anti – plasmin, anti – trypsin A1 plasminogen activator and endothelial prostacyclin stimulator were also reduced.

After we get to know the reasons of these symptoms and then we can accept the reasonable treatment in time,if you have other questions about that please contact us through the following message:

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Tag: Nephrotic Syndrome   Reasonable treatment   Hypercoagulable state   Fibrinogen catabolism   Fibrin and fibrinogen degradation  
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