Predicting First-Year Relapses in Children With Nephrotic Syndrome

2014-04-08 10:08

Definition

Nephrotic syndrome is a kidney disorder characterized by a large amount of proteinuria. Nephrotic syndrome is usually caused by damage to the clusters of small blood vessels in your kidneys that filter waste and excess water from your blood. Nephrotic syndrome causes swelling (edema), particularly in your feet and ankles, and increases the risk of other health problems.

Symptoms

• Edema

• Proteinuria

• Hyperlipidemia

• Hypercoagulability

More than half of the children diagnosed with Nephrotic syndrome will have relapses. These can be infrequent relapses (IRs: <2 in 6 months or <3 in a year) or frequent relaspses (FRs: >2 in 6 months or >3 in a year). Children who relapse while on alternate day steroids are considered steroid-dependent. People with minimal- change disease and meanwhile without mesangial hypercellularity or sclerosis, the prognosis will be better.If you want a peosonalized analysis, please email us at kidneyservice@hotmail.com

What are initial factors that could predict the relapse pattern in the first year after diagnosis without taking into consideration the histopathology found on renal biopsy?

If you analyzed the medical records of children for one year, you may find age, sex, race, and hematuria were not predictors of relapses in the first year. If the remission occurred within the first week of therapy, the patients without hematuria were more likely to be IR.

Concluding all the presenting features, the rapidity of initial response to steroid therapy combined with the presence of hematuria, could predict future relapses and should be well documented. Any questions? please chat with our online doctor.

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Tag: Nephrotic Syndrome Basics   First-Year Relapsesin Children  
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