What Damage Can be Induced by Massive Proteinuria of Chronic Kidney Disease

2014-07-18 15:35

Proteinuria as a common symptoms of Chronic Kidney Disease, has long been regarded as a result of this disease. But in fact, the amount of protein in urine and exception of it is not only a lesion index, but as an independent factors participate in the process of kidney disease, so the harm to human body is great. Then what damage can be induced by massive proteinuria of Chronic Kidney Disease ?

1. Proteinuria has toxic effects on glomerular mesangial cell. After enter into Kidney Failure, large amount of plasma protein will deposit in glomerular mesangial area, which may cause damage, proliferation and mesangial matrix generation increases, resulting in glomerular sclerosis;

2. Urinary protein may cause damage to renal tubule interstitial. Under normal circumstances, a small amount of small molecule protein filtration by glomerular is absorbed by renal tubular epithelial cells, decomposition in soluble enzyme. Under pathological condition, with increased glomerular permeability of a large number of plasma protein leakage to the renal tubules lumen, and proximal renal tubular epithelial cells to absorb albumin lead to excessive weight intracytoplasmic lysosome increased activity, that can cause cell damage;

3. A large amount of proteinuria increase renal tubular reabsorption of protein, help to increase the production of ammonia, and the production of ammonia in the kidney tissues also play a role in progressive interstitial lesions. In addition, extra energy absorption and digestion of protein can result in tubular cells of oxygen and oxygen free radical generation induce tubular cell damage.

From the above we know that massive proteinuria of Chronic Kidney Disease can induce damage to glomerular mesangial cell, renal tubule interstitial and tubular cell, so do pay attention to it. If there are large amount of protein in your urine, you should go to see your doctor in time, do not let it make further damage to your renal. For further informations, please email us. Our email: kidneyservice@hotmail.com

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Tag: Chronic Kidney Disease   Massive proteinuria   CKD Basics  
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